Test Entry - Detail

TPA

General

Clinical Use:

TPA is a serine protease, mainly synthesized by endothelial cells and rapidly cleared by the liver. It plays an important role in fibrinolysis. tPA initiates the fibrinolytic process and activates plasminogen to plasmin. In the presence of fibrin, the activation of plasminogen becomes greatly accelerated, formation of a ternary complex between tPA, fibrin and plasminogen in which tPA has an increased affinity for plasminogen. A large proportion of tPA circulates in the inactive form, the latter being complexed with its inhibitor (PAI-1). Only the free form is active. Increased levels have been reported in inflammatory syndrome, myocardial infarction, respiratory distress, septicaemia and severe hepatic disorders. High concentrations seem to be a risk marker for cardiovascular diseases. Decreased release of tPA has been associated with risks of thrombosis.

Availability:

Samples are batched and tested once a month.
Please contact testing laboratory for urgent requests.

Aliases/Synonyms:

Tissue Plasminogen Activator, Tissue Plasminogen Assay,

Code:

TPL

Handling Instructions (to laboratory):

Send whole sample ambient.
Send separated sample frozen on dry ice.

Hyperlink:

Reference Interval:

1-12ng/mL

Collection Requirements

Container:

Sodium Citrate-3.2% (BLUE),

Sample Type:

See container

Minimum Collection Volume:

2.7mL

Collection Instructions:

If sample will not reach laboratory within 4 hours of collection, it must be double centrifuged, separated and frozen.

Processing Requirements

Alternate Containers:

Processing Instructions:

Minimum Assay Volume:

2.7mL

Stability:

4 hours ambient

Transport Instructions (to testing laboratory):

Send separated sample frozen on dry ice.

Testing Locations

Performed at:

Section	Department	Site	Contact Phone
Coagulation	Haematology	Fiona Stanley Hospital	6152 8135

Last Updated : 02-12-2020 07:19