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General
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Clinical Use:
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Therapeutic drug monitoring.
Clomipramine is a tricyclic antidepressant medication, used for treatment of OCD - Obsessive-compulsive disorder. Desmethylclomipramine, a metabolite of clomipramine is also quantified in this assay. |
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Availability:
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Samples are batched and tested once a week. |
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Aliases/Synonyms:
| Desmethylclomipramine, Norclomipramine, |
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Code:
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CLOM |
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Handling Instructions (to laboratory):
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Send sample chilled. |
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Hyperlink:
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Reference Interval:
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Therapeutic range: 220-500 µg/L. Toxicity threshold: >900 µg/L.
Clomipramine is metabolised to norclomipramine. The parent drug
and the metabolite are pharmacologically active.
TDM should include assay of both clomipramine and norclomipramine.
The therapeutic range is 220 to 500 µg/L when the concentration of both
compounds is summed. Toxicity may be seen at total concentrations
greater than 900 µg/L.
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Collection Requirements
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Container:
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Serum, no gel (RED), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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2mL |
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Collection Instructions:
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Collect sample prior to dose as trough level.
Record date, time and dosage of last dose on request form. |
Processing Requirements
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Alternate Containers:
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Lithium Heparin, No Gel (DKGNLITH) |
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Processing Instructions:
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Centrifuge and separate sample. |
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Minimum Assay Volume:
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1mL |
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Stability:
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Transport Instructions (to testing laboratory):
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Send sample chilled. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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Laboratory |
SSWPS-Royal Prince Alfred Hospital |
(02) 9515 8279 |
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Last Updated : 03-10-2020 10:53 |