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General
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Clinical Use:
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Therapeutic drug monitoring. Desipramine is a tricyclic antidepressant medication. Although it is also a metabolite of imipramine it is sometimes given on its own as a medication and is requested on its own for quantification. |
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Availability:
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Samples are batched and tested once a week. |
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Aliases/Synonyms:
| Desipramine, Norpramin, |
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Code:
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IMP |
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Handling Instructions (to laboratory):
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Send sample chilled. |
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Hyperlink:
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Reference Interval:
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Imipramine (Metabolised to Desipramine)
Therapeutic Range:
Imipramine + Desipramine = 0.46-1.02 umol/L
Toxic: Imipramine + Desipramine > 1.84 umol/L
Conversion for Imipramine: umol/L x 0.2804 = ug/mL
Therapeutic range: Plasma drug levels which are established to be effective in the treatment of the disease.
Desipramine:
Therapeutic Range: 0.56 - 1.13 umol/L
Possible toxicity : >1.13 umol/L
Toxic level: > 1.88 umol/L
Conversion for Desipramine: umol/L x 0.2664 = ug/mL
Ref: Up to Date, 2006, www.uptodate.com
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Collection Requirements
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Container:
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Serum, no gel (RED), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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3mL |
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Collection Instructions:
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Collect sample prior to dose as trough level.
Record date, time and dosage of last dose on request form. |
Processing Requirements
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Alternate Containers:
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Lithium Heparin, No Gel (DKGNLITH) |
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Processing Instructions:
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Centrifuge and separate sample. |
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Minimum Assay Volume:
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1mL |
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Stability:
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Transport Instructions (to testing laboratory):
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Send sample chilled. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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Laboratory |
SSWPS-Royal Prince Alfred Hospital |
(02) 9515 8279 |
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Last Updated : 05-10-2020 07:41 |