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General
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Clinical Use:
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Therapeutic drug monitoring. Dothiepin is a tricyclic antidepressant medication. Desmethyldothiepin, a metabolite of dothiepin is also quantified in this assay. |
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Availability:
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Samples are batched and tested once a week. |
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Aliases/Synonyms:
| Desmethyldothiepin, |
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Code:
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DOTH |
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Handling Instructions (to laboratory):
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Send sample chilled. |
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Hyperlink:
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Reference Interval:
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Therapeutic range is undefined.
Metabolised to Nordothiepin.
At RPAH, 95% of Dothiepin estimations have been in the range 0.0-1.78 umol/L while 95% of Nordothiepin estimations have been in the range 0.0-0.69 umol/L. Current literature indicates there is no correlation between plasma concentration and therapeutic effect.
A ratio of Nordothiepin/Dothiepin of > 1.15, however, may indicate poor compliance.
Plasma Dothiepin concentrations > 2.0 umol/L has been associated with symptoms of toxicity.
Conversion: umol/L x 0.2954 = ug/mL
Therapeutic Concentration: Plasma drug levels achieved at certain time after administering a certain dosage, but its effectiveness against the disease has not been established.
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Collection Requirements
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Container:
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Serum, no gel (RED), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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3mL |
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Collection Instructions:
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Collect sample prior to dose as trough level.
Record date, time and dosage of last dose on request form. |
Processing Requirements
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Alternate Containers:
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Lithium Heparin, No Gel (DKGNLITH) |
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Processing Instructions:
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Centrifuge and separate sample. |
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Minimum Assay Volume:
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1mL |
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Stability:
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Transport Instructions (to testing laboratory):
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Send sample chilled. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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Laboratory |
SSWPS-Royal Prince Alfred Hospital |
(02) 9515 8279 |
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Last Updated : 05-10-2020 07:42 |