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General
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Clinical Use:
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TPMT genotyping is important in determining a patient's susceptibility to reduced TPMT activity. The TPMT enzyme is involved the metabolism of thiopurine drugs including 6-mercaptopurine (6MP) and 6-thioguanine (6TG) and azathioprine (AZA). Decreased activity of this enzyme is associated with potentially fatal drug toxicity.
TPMT genotyping screens exons 5, 7 and 10 of the TPMT gene for the most commonly documented mutations that have been shown to result in reduced TPMT activity. |
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Availability:
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Samples are tested routinely during the testing laboratory's hours of operation. |
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Code:
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GTSMG |
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Handling Instructions (to laboratory):
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Send sample ambient. |
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Hyperlink:
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Reference Interval:
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Not Applicable
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Collection Requirements
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Container:
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EDTA (LAVENDER), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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4mL |
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Collection Instructions:
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Processing Requirements
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Alternate Containers:
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Processing Instructions:
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Store sample at room temperature.
Do not centrifuge sample. |
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Minimum Assay Volume:
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4mL |
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Stability:
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72 hours ambient; Indefinitely once extracted and frozen |
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Transport Instructions (to testing laboratory):
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Send sample ambient. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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| Molecular Genetics |
Diagnostic Genomics |
QEII Medical Centre |
6383 4243 |
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Last Updated : 14-10-2020 14:53 |