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General
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Clinical Use:
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Total bile acids are metabolised in the liver and hence serve as a marker for normal liver function. Serum total bile acids are increased in patients with acute hepatitis, chronic hepatitis, liver sclerosis, liver cancer and obstetric cholestasis.
Intrahepatic cholestasis of pregnancy (ICP) is a disease characterised by generalised pruritus and biochemical cholestasis that appears typically during the last trimester of gestation. Total bile acids is one of the more predictive and accurate markers for the diagnosis and follow up of ICP. Although essentially benign for the mother, evidence associates ICP with poor fetal prognosis resulting from increased transfer of bile salts from mother to fetus, who showed reduced ability to eliminate bile acids across the placenta. |
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Availability:
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Samples are tested routinely during the testing laboratory's hours of operation. |
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Aliases/Synonyms:
| Bile Acids, Bile Salts, |
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Code:
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TBA |
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Handling Instructions (to laboratory):
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Send sample chilled. |
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Hyperlink:
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Reference Interval:
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Fasting:
0d to <31d: <35
1m to <6m: <20
6m to <1y: <15
1y to <120y: <6
Random: <10 umol/L
Two hour post-prandial levels normally increase <40%
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Collection Requirements
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Container:
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Serum Sep. Tube-SST (GOLD), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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1mL |
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Collection Instructions:
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Please note that Fasting is not required (unless specified by the requesting doctor). |
Processing Requirements
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Alternate Containers:
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Lithium Heparin-PST (GREEN) |
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Processing Instructions:
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Minimum Assay Volume:
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0.5mL |
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Stability:
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7 days chilled; 3 months frozen |
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Transport Instructions (to testing laboratory):
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Send sample chilled. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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| Core |
Biochemistry |
QEII Medical Centre |
6383 4093 |
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Last Updated : 16-01-2024 11:05 |