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General
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Clinical Use:
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Cryoglobulins are single proteins or protein (immune)complexes that have the property of coming out of solution when the body temperature drops below 37 deg C. Cryoglobulins form clusters that can block small blood vessels, especially in the face and hands. Upon re-warming the body to 37deg C Cryoglobulins return to their soluble state.
This test is most often done when a person's symptoms suggest a condition that associated with Cryoglobulins. Cryoglobulins are associated with several disorders, including those that affect the skin, joints, kidneys, and nervous system. They should be assessed with myeloma patients. |
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Availability:
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The cryoglobulin test is set up daily and the results are monitored over 7 days. The report will be available 8 days after sample collection. |
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Aliases/Synonyms:
| Cryoprecipitate, |
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Code:
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CRYGL |
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Handling Instructions (to laboratory):
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Processing days: Samples to be delivered to FSH or QEII before 2pm Monday-Friday.
If processing samples at QEII or FSH, deliver sample at 37 degrees to the laboratory within 2 hours of collection.
All other processing sites: See collection requirements below. |
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Hyperlink:
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Unit of Measure:
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Refer to reference interval |
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Reference Interval:
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Not Detected
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Collection Requirements
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Container:
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Serum, no gel x 3 (RED), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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20mL (>12 years); 5mL (<12 years) |
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Collection Instructions:
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Preferable that patient is fasting.(Lipid can interfere with the assay).
Pre-warm needle, syringe and blood tubes to 37 degrees.
Collect sample at 37 degrees, incubate and transport to processing lab at 37 degrees. |
Processing Requirements
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Alternate Containers:
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Processing Instructions:
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The testing department should be contacted to arrange collection of sample from CSRA.
If sample has been chilled, it must remain at 4 degrees for duration of testing.
Samples being processed at FSH or QEII must be delivered to the laboratory before 2pm Monday-Friday.
Samples processed outside of FSH and QEII, must be incubated for 2 hours at 37 degrees, then centrifuged (2000g) at 37 degrees for 10 minutes. Serum (minimum 4ml) is separated from the primary tube and forwarded to FSH or QEII in allocated aliquot tubes.
The separated sample can be transported at room temperature. |
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Minimum Assay Volume:
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4mL |
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Stability:
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2 hours at 37 degrees |
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Transport Instructions (to testing laboratory):
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Send separated sample ambient. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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Immunology |
Fiona Stanley Hospital |
6152 8006 |
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Immunology |
QEII Medical Centre |
6383 4306 |
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Last Updated : 18-06-2026 09:28 |