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General
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Clinical Use:
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To determine if the concentration of digoxin in the blood is at a therapeutic level or to detect toxic levels.
It takes 7 to 8 days to reach steady state.
All digoxin requests on patients <=60 days will reflex to Free Digoxin. Total Digoxin will not be performed. This is because of the possible interference from Digoxin like immunoreactive factors on the Abbott digoxin assay. |
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Availability:
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Samples are tested routinely during the testing laboratory's hours of operation. |
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Aliases/Synonyms:
| Lanoxin, |
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Code:
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DIG |
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Handling Instructions (to laboratory):
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Send sample chilled. |
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Hyperlink:
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Reference Interval:
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Revised Therapeutic Range (6 hours post dose):
Heart failure patients in sinus rhythm: 0.5-0.9ug/L.
For ventricular rate control in chronic atrial fibrillation: <1.2ug/L
Heart failure patients in sinus rhythm show decreased mortality and hospitalisation when digoxin levels are in the range 0.5-0.9ug/L.
The risk of death in patients who are taking digoxin for ventricular rate control in chronic atrial fibrillation has been shown to be independently related to serum digoxin
concentration and was highest in patients with concentrations of 1.2ug/L or more.
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Collection Requirements
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Container:
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Lithium Heparin-PST (GREEN), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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300uL |
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Collection Instructions:
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Sample should be collected at least 6 hours after last dose.
Record date, time and dosage of last dose on request form.
If sample will not reach laboratory within 24 hours of collection, it must be centrifuged and separated from gel. |
Processing Requirements
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Alternate Containers:
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Lithium Heparin, No Gel (DKGNLITH) |
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Serum, no gel (RED) |
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Processing Instructions:
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Minimum Assay Volume:
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100uL |
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Stability:
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24 hours chilled (unseparated); 2 days chilled (separated) |
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Transport Instructions (to testing laboratory):
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Send sample chilled. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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| Core |
Biochemistry |
Fiona Stanley Hospital |
6152 8140 |
| Core |
Biochemistry |
QEII Medical Centre |
6383 4093 |
| Core |
Biochemistry |
Royal Perth Hospital |
9224 1176 |
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Last Updated : 30-04-2024 12:36 |