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Fibroblast Growth Factor 23
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General
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Clinical Use:
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Fibroblast growth factor 23 (FGF23) is a major regulator of phosphate homeostasis.
FGF23 is secreted primarily by bone, followed by thymus,
heart, brain and, in low levels, by several other tissues. It is coexpressed with the X-linked phosphate-regulating endopeptides(PHEX).
Only intact FGF23 is considered bioactive. It interacts with a specific receptor on renal tubular cells, decreasing expression of type IIa sodium/phosphate cotransporters, resulting in
decreased phosphate reabsorption. In addition, gene transcription of 1-a hydroxylase is downregulated, reducing
bioactive 1,25-dihydroxy vitamin D (1,25-2OH-VitD), thereby further decreasing phosphate reabsorption.
Measurement of serum FGF23 can assist in diagnosis and
management of disorders of phosphate and bone metabolism in patients with either normal or impaired renal function. |
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Availability:
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Aliases/Synonyms:
| FGF-23, FGF23, |
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Code:
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FGF |
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Handling Instructions (to laboratory):
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Send sample chilled. |
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Hyperlink:
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Reference Interval:
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Refer to report or laboratory
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Collection Requirements
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Container:
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EDTA (LAVENDER), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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2mL |
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Collection Instructions:
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Non-medicare rebateable item. All patients except Public, VA and Pensioners must pay $101.00 upfront. |
Processing Requirements
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Alternate Containers:
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Processing Instructions:
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Centrifuge, separate and freeze sample. |
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Minimum Assay Volume:
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Stability:
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Transport Instructions (to testing laboratory):
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Send separated sample frozen on dry ice.
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Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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Laboratory |
Royal North Shore Hospital |
(02) 9926 7111 |
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Last Updated : 14-02-2024 16:03 |