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Clinical Use:
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Platinum compounds are used in electrodes, jewellery, dental alloys, surgical and laboratory tools, chemical manufacturing, some cancer drugs; cisplatin, carboplatin and oxaliplatin, glass manufacturing; LCD screens and optical fibres.
Toxicity is determined by the type of compound (e.g., metallic, inorganic salt, or organometallic), route of exposure (e.g., intravenous medicinal use, inhalational, cutaneous, oral), and duration of exposure.
Soluble platinum salts encountered in occupational settings can cause signs and symptoms of hypersensitivity including urticaria, contact dermatitis of the skin, and respiratory disorders ranging from sneezing, shortness of breath, and cyanosis to severe asthma. Platinum metal and insoluble salts can cause eye irritation.
Anaphylactic reactions have been noted in patients treated with platinum anti-tumour agents. |