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General
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Clinical Use:
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This assay is used to determine the Factor V Leiden gene status following a request for activated protein C resistance or Factor V Leiden.
Up to 90% of APCR is due to a single mutation of the Factor V gene (Factor V Leiden). The Factor V Leiden mutation has a prevalence of about 10% in the general population (9.5% heterozygous, 0.7% homozygous). It is the most common cause of inherited thrombophilia.
Patients heterozygous for the Factor V Leiden mutation have an 8-fold increased risk of venous thrombosis. This risk increases to 100 fold in a homozygous patient. Risks are further increased with the oral contraceptive pill.
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Availability:
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Samples are batched and tested twice a week. |
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Aliases/Synonyms:
| Activated Protein C Resistance, APC Resistance, aPCR, F5L, FVL, |
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Code:
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HFVL |
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Handling Instructions (to laboratory):
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Send sample chilled. |
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Hyperlink:
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Reference Interval:
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Results are reported as homozygous,
heterozygous or not detected for the Factor V Leiden gene mutation
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Collection Requirements
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Container:
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EDTA (LAVENDER), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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3mL |
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Collection Instructions:
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Processing Requirements
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Alternate Containers:
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Processing Instructions:
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Minimum Assay Volume:
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1mL |
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Stability:
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15 days chilled |
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Transport Instructions (to testing laboratory):
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Send sample chilled. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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| Coagulation |
Haematology |
Fiona Stanley Hospital |
6152 8135 |
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Last Updated : 05-03-2021 15:56 |