Test Entry - Detail

Cryofibrinogen

General

Clinical Use:

Pathology in cryofibrinogenaemia is thought to be secondary to thrombotic occlusion of medium and small arteries with features of vasculitis, most commonly cutaneous ischaemia including purpura, livedo reticularis, ulceration and necrosis. Cryofibrinogens may be primary ('idiopathic') or more commonly secondary to underlying inflammatory condition such as infection, malignancy or connective tissue disease. Cryofibrinogens may occasionally be seen in normal healthy individuals, usually at low levels. Cryofibrinogens cannot be assesed without a corresponding Cryoglobulin (serum) sample.

Availability:

The cryoglobulin test is set up daily and the results are monitored over 7 days. The report will be available 8 days after sample collection.

Code:

CRYFB

Handling Instructions (to laboratory):

Processing days: Samples to be delivered to FSH or QEII before 2pm Monday to Fridays.
If processing samples at QEII or FSH, deliver sample at 37 degrees to the laboratory within 2 hours of collection.
All other processing sites: See collection requirements below.

Hyperlink:

Unit of Measure:

Refer to reference interval

Reference Interval:

Not Detected

Collection Requirements

Container:

EDTA x 5 (LAVENDER),

Sample Type:

See container

Minimum Collection Volume:

20mL (>12 years); 5mL (<12 years)

Collection Instructions:

Please also refer to collection of Cryoglobulins as these 2 tests are performed together.
Preferable that patient is fasting. (Lipid can interfere with the assay).
Pre-warm needle, syringe and blood tubes to 37 degrees.
Collect sample at 37 degrees, incubate and transport to processing lab at 37 degrees.

Processing Requirements

Alternate Containers:

Processing Instructions:

The testing department should be contacted to arrange collection of sample from CSRA.
If sample has been chilled, it must remain at 4 degrees for duration of testing.
Samples being processed at FSH or QEII must be delivered to the laboratory before 2pm Monday-Friday.
Sample processed outside of FSH and QEII, must be incubated for 2 hours at 37 degrees, then centrifuged (2000g) at 37 degrees for 10 minutes. Serum (minimum 4ml) is separated from the primary tube and forwarded to FSH or QEII in allocated aliquot tubes.
The separated sample can be transported at room temperature.

Minimum Assay Volume:

4mL

Stability:

2 hours at 37 degrees;

Transport Instructions (to testing laboratory):

Send separated sample ambient.

Testing Locations

Performed at:

Section	Department	Site	Contact Phone
-	Immunology	Fiona Stanley Hospital	6152 8006
-	Immunology	QEII Medical Centre	6383 4306

Last Updated : 18-06-2026 09:37