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Detection of Somatic Variants in Cell Free DNA
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General
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Clinical Use:
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Some somatic variants, such as EGFR p.T790M and BRAF p.V600E, can be detected in circulating tumour DNA (ctDNA), also known as cell free DNA (cfDNA), which is isolated from a patient blood sample. This is frequently termed 'liquid biopsy' and has the advantage of being relatively easy to obtain compared to tissue biopsy and therefore could be used when a tissue biopsy is not recommended by the clinician.
Please note that these tests can also be carried out on FFPE tissue and cytology specimens such as pleural or ascitic fluid. These specimens should be sent directly to the laboratory in a sterile container.
Please contact the testing laboratory to discuss gene tests available. |
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Availability:
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Samples are tested routinely during the testing laboratory's hours of operation.
Please contact testing laboratory for urgent requests. |
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Aliases/Synonyms:
| Cell Free DNA, Cell-Free Tumour DNA, cf DNA, cf-DNA, cfDNA, Circulating Tumour DNA, ct-DNA, ctDNA, EGFR T790M, EGFR T790M, |
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Code:
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HST |
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Handling Instructions (to laboratory):
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Send sample ambient immediately following collection.
Store sample chilled if delivery will be delayed. |
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Hyperlink:
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Reference Interval:
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Not Applicable
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Collection Requirements
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Container:
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Streck (STRECK) x 2, |
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Sample Type:
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See container |
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Minimum Collection Volume:
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10mL |
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Collection Instructions:
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Non-medicare rebateable item. All patients except Public, VA and Pensioners must pay $362.59 upfront. |
Processing Requirements
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Alternate Containers:
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Streck (STRECK) |
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Processing Instructions:
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Minimum Assay Volume:
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Stability:
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7 days ambient |
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Transport Instructions (to testing laboratory):
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Send sample ambient immediately following collection.
Store sample chilled if delivery will be delayed. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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| Molecular Pathology |
Anatomical Pathology |
QEII Medical Centre |
6457 2679 |
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Last Updated : 19-01-2026 11:11 |