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Detection of MGMT Methylation in Glioma
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General
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Clinical Use:
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In patients with glioblastoma there is a strong correlation between methylation of MGMT and positive clinical outcome for those treated with alkylating agents (Hegi et al, 2008).
Loss of MGMT expression due to methylation occurs in ~40% of GBM and this test is intended to aid clinicians in the selection of glioblastoma cancer patients which are more likely to benefit from treatment with alkylating agents. |
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Availability:
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Samples are tested routinely during the testing laboratory's hours of operation.
Please contact testing laboratory for urgent requests. |
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Aliases/Synonyms:
| MGMT Hypermethylation, MGMT Methylation Studies, MGMT Promoter Methylation, MGMTp, |
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Code:
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HST |
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Handling Instructions (to laboratory):
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Contact testing laboratory for specific transport instructions. |
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Hyperlink:
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Reference Interval:
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Not Applicable
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Collection Requirements
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Container:
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Sterile Container (STERILE), |
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Sample Type:
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Fresh/Frozen Tissue; Formalin Fixed or FFPE Tissue; Cytological Fluid Samples; FNA |
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Minimum Collection Volume:
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N/A |
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Collection Instructions:
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Contact testing laboratory for specific collection instructions. |
Processing Requirements
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Alternate Containers:
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Processing Instructions:
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Minimum Assay Volume:
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N/A |
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Stability:
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Dependent on sample type |
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Transport Instructions (to testing laboratory):
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Contact testing laboratory for specific transport instructions. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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| Molecular Pathology |
Anatomical Pathology |
QEII Medical Centre |
6457 2679 |
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Last Updated : 06-11-2020 14:00 |