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MLH1 Promoter Methylation Test for Endometrial and Colon Cancer
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General
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Clinical Use:
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This test is part of reflex testing for colorectal and endometrial cancers to determine the likelihood of hereditary non-polyposis colorectal cancer syndrome (HNPCC) or Lynch Syndrome.
Analysis of MLH1 promoter methylation is typically performed after immunohistochemistry to detect loss of expression of mismatch repair genes (MLH1, MSH2, MSH6 and PMS2) and/or microsatellite instability (MSI) molecular testing in order to further stratify sporadic and hereditary cases. |
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Availability:
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Samples are tested routinely during the testing laboratory's hours of operation.
Please contact testing laboratory for urgent requests. |
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Aliases/Synonyms:
| MLH1p, MLPA, MS-MLPA, |
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Code:
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HST |
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Handling Instructions (to laboratory):
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Contact testing laboratory for specific transport instructions. |
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Hyperlink:
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Reference Interval:
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Not Applicable
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Collection Requirements
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Container:
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Sterile Container (STERILE), |
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Sample Type:
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Fresh/Frozen Tissue; Formalin Fixed or FFPE Tissue; Cytological Fluid Samples; FNA |
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Minimum Collection Volume:
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N/A |
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Collection Instructions:
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Contact testing laboratory for specific collection instructions. |
Processing Requirements
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Alternate Containers:
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Processing Instructions:
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Minimum Assay Volume:
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N/A |
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Stability:
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Dependent on sample type |
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Transport Instructions (to testing laboratory):
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Contact testing laboratory for specific transport instructions. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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| Molecular Pathology |
Anatomical Pathology |
QEII Medical Centre |
6457 2679 |
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Last Updated : 06-11-2020 14:23 |