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Microsatellite Instability Test
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General
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Clinical Use:
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Testing for microsatellite instability in colorectal carcinomas is performed to identify patients who may have hereditary non-polyposis colorectal carcinoma (HNPCC), also known as Lynch Syndrome (LS).
Lynch syndrome is an autosomal dominant inherited condition resulting from an inactivating mutation in one of the mismatch repair genes (MLH1, MSH2, MSH6 and PMS2). It is associated with increased risk of colorectal (CRC), endometrial and other cancers. The microsatellite instability (MSI) phenotype is characteristic of HNPCC/LS although it also occurs in approximately 15% of sporadic colon cancers. Thus, this test is used as a screening tool to identify patients at risk of HNPCC/LS. |
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Availability:
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Samples are tested routinely during the testing laboratory's hours of operation.
Please contact testing laboratory for urgent requests. |
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Aliases/Synonyms:
| MSI Fragment Analysis, |
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Code:
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HST |
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Handling Instructions (to laboratory):
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Contact testing laboratory for specific transport instructions. |
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Hyperlink:
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Reference Interval:
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Not Applicable
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Collection Requirements
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Container:
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Sterile Container (STERILE), |
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Sample Type:
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Fresh/Frozen Tissue; Formalin Fixed or FFPE Tissue; Cytological Fluid Samples; FNA |
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Minimum Collection Volume:
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N/A |
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Collection Instructions:
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Contact testing laboratory for specific collection instructions. |
Processing Requirements
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Alternate Containers:
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Processing Instructions:
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Minimum Assay Volume:
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N/A |
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Stability:
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Dependent on sample type |
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Transport Instructions (to testing laboratory):
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Contact testing laboratory for specific transport instructions. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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| Molecular |
Anatomical Pathology |
QEII Medical Centre |
6457 2679 |
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Last Updated : 12-11-2020 16:48 |