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Detection of Somatic Variants in the NRAS Gene
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General
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Clinical Use:
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Activation of the NRAS oncogene is implicated in various human tumours. Approximately 18% of melanomas and 3-4% of colorectal cancers (CRC) have an activating variant in NRAS. The large majority (~87%) of activating NRAS variants occur in codon 61 of exon 3, with rare variants also seen in codons 12 and 13 of exon 2 and codon 59 of exon 3 and codons 117 and 146 of exon 4.
The presence of NRAS activating variant is a prognostic marker in melanoma and in patients with metastatic colorectal it is a negative predictor of response to anti-EGFR monoclonal antibody therapy.
This test is Medicare rebateable for metastatic colorectal cancer (stage IV). |
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Availability:
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Samples are tested routinely during the testing laboratory's hours of operation.
Please contact testing laboratory for urgent requests. |
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Aliases/Synonyms:
| Neuroblastoma RAS Viral Oncogene, |
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Code:
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HST |
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Handling Instructions (to laboratory):
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Contact testing laboratory for specific transport instructions. |
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Hyperlink:
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Reference Interval:
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Not Applicable
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Collection Requirements
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Container:
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Sterile Container (STERILE), |
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Sample Type:
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Formalin Fixed or FFPE Tissue; Fresh/Frozen Tissue; Bone Marrow Trephine; Bone Marrow Aspirate; Cytological Fluid Samples; FNA |
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Minimum Collection Volume:
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N/A |
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Collection Instructions:
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Contact testing laboratory for specific collection instructions. |
Processing Requirements
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Alternate Containers:
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Processing Instructions:
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Minimum Assay Volume:
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N/A |
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Stability:
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Dependent on sample type |
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Transport Instructions (to testing laboratory):
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Contact testing laboratory for specific transport instructions. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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| Molecular |
Anatomical Pathology |
QEII Medical Centre |
6457 2679 |
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Last Updated : 12-11-2020 17:21 |