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Detection of Somatic Variants in the PDGFRa Gene
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General
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Clinical Use:
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Detection of somatic variants in exons 12, 14 and 18 of the PDGFRa (Platelet derived growth factor receptor alpha, also known as PDGFRA) gene in gastrointestinal stromal tumours (GIST) is used to select patients suitable for tyrosine kinase inhibitors (e.g. imatinib, gleevec, avapritinib). Approximately 5-7% GISTs harbour variants in PDGFRa and they are usually mutually exclusive with KIT variants, which are present in around 80% of GISTs. |
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Availability:
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Samples are tested routinely during the testing laboratory's hours of operation.
Please contact testing laboratory for urgent requests. |
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Aliases/Synonyms:
| Platelet Derived Growth Factor Receptor Alpha, |
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Code:
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HST |
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Handling Instructions (to laboratory):
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Contact testing laboratory for specific transport instructions. |
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Hyperlink:
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Reference Interval:
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Not Applicable
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Collection Requirements
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Container:
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Sterile Container (STERILE), |
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Sample Type:
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Formalin Fixed or FFPE Tissue; Fresh/Frozen Tissue; Bone Marrow Trephine; Bone Marrow Aspirate; Cytological Fluid Samples; FNA |
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Minimum Collection Volume:
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N/A |
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Collection Instructions:
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Contact testing laboratory for specific collection instructions. |
Processing Requirements
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Alternate Containers:
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Processing Instructions:
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Minimum Assay Volume:
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N/A |
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Stability:
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Dependent on sample type |
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Transport Instructions (to testing laboratory):
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Contact testing laboratory for specific transport instructions. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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| Molecular |
Anatomical Pathology |
QEII Medical Centre |
6457 2679 |
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Last Updated : 12-11-2020 18:32 |