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Dihydropryrimidine dehydrogenase
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General
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Clinical Use:
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The protein dihydropyrimidine dehydrogenase is involved in the breakdown of various drugs. Variants in the protein's gene, DPYD, can slow the rate at which certain drugs are broken down.
The drugs involved are 5-fluorouracil (5FU), capecitabine and tegafur. A patient with such a variant may be at risk of bone marrow toxicity from the medication.
The laboratory report describes the gene variants detected in a patient, and the implications regarding drug choice or dose according to current evidence-based guidelines. |
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Availability:
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Aliases/Synonyms:
| Capecitabine, DHPDHASE, DPYD, Tegafur, |
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Code:
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DPYD |
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Handling Instructions (to laboratory):
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Send sample ambient. |
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Hyperlink:
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Reference Interval:
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Not Applicable
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Collection Requirements
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Container:
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EDTA (LAVENDER), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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Collection Instructions:
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Dedicated sample required.
Please list current and proposed medications on the request form. Please highlight any medications that have caused problems in the past.
Non-medicare rebateable item. All patients except Public, VA and Pensioners must pay $160 upfront. |
Processing Requirements
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Alternate Containers:
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Processing Instructions:
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Minimum Assay Volume:
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Stability:
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Transport Instructions (to testing laboratory):
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Send sample ambient. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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Laboratory |
Sonic Genetics |
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Last Updated : 10-11-2025 08:11 |