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General |
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| Clinical Use: | Assessment of patients with suspected autoimmune encephalitis and autoimmune limbic encephalitis. A variety of clinical features may accompany these disorders including, but not limited to, refractory seizures; cerebellar ataxia; dyskinesias and movement disorders; neuropsychiatric symptoms; dysautonomia. Requests for urgent testing must be discussed directly with an immunopathologist. Autoimmune encephalitis antibody panel includes antibodies to: NMDA-Receptor, LGI1 & CASPR2 (also known as VGKC antibodies); GABA-R-B1/B2; AMPA-R1/2; ANNA-1 (Hu); ANNA-2 (Ri); PCA1 (Yo); CRMP5 (CV2); Amphiphysin; Ma1 and Ma2; Tr (DNER). |
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| Availability: | Samples are batched and tested once a week. | |||||||||
| Aliases/Synonyms: | Autoimmune Encephalitis (Auto)Antibodies (CSF), Autoimmune Encephalitis (CSF), Limbic Encephalitis (Auto)Antibodies (CSF), Limbic Encephalitis Panel (CSF), | |||||||||
| Code: | LEABC | |||||||||
| Handling Instructions (to laboratory): | Samples from the Perth metro area may be transported chilled. Samples from regional or external labs should be stored and transported frozen. |
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| Hyperlink: | https://pathwest.health.wa.gov.au/~/media/PathWest/Documents/Our-Services/Clinical-Services/Immunology/Testing-for-Neuroimmunology-Conditions-at-PathWest-Laboratory-Medicine.pdf | |||||||||
| Reference Interval: |
Results are reported as Detected, Not Detected or Not Excluded. |
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Collection Requirements |
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| Container: | CSF Tube 1 (CSF1), | |||||||||
| Sample Type: | CSF | |||||||||
| Minimum Collection Volume: | 200µl | |||||||||
| Collection Instructions: | ||||||||||
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Processing Requirements |
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| Alternate Containers: |
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| Processing Instructions: | ||||||||||
| Minimum Assay Volume: | 200µl | |||||||||
| Stability: | ||||||||||
| Transport Instructions (to testing laboratory): | Send sample chilled if sample will be received at QEII within 24hrs of collections. Samples delayed >24hrs should be sent frozen. |
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Testing Locations |
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| Performed at: |
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Last Updated : 04-03-2026 14:06 |
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