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General |
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| Clinical Use: | Thiocyanates are a group of compounds formed from a combination of Sulphur, Carbon, and Nitrogen. Cyanide is rapidly converted to thiocyanate via rhodanase in the liver. Ammonium thiocyanate is used in antibiotic preparations, pesticides, liquid rocket fuels, adhesives, and matches. As hydrogen cyanide is present in cigarette smoke, the excretion of thiocyanate in urine, saliva, and sweat can provide a useful marker of exposure in smokers and non-smokers. Thiocyanate is also a metabolite of Sodium nitroprusside (SNP), an antihypertensive agent. Symptoms of cyanide poisoning include dizziness, hyperpnoea (rapid, deep breathing), weakness, mental and motor impairment and sudden death respiratory paralysis. Absorption into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood). Exposure to small amounts of cyanide can be deadly regardless of the route of exposure - by inhalation of hydrocyanic acid or ingestion of salts; fumes from nitrogen products containing cyanide are also a hazard to fire-fighters. | |||||||||
| Availability: | Samples are batched and tested once a week. | |||||||||
| Aliases/Synonyms: | Cyanide (Spot Urine), | |||||||||
| Code: | UTHIO | |||||||||
| Handling Instructions (to laboratory): | Send sample chilled. | |||||||||
| Hyperlink: | https://catalogue.pathology.health.nsw.gov.au/attachment/8eee010b-ce47-4b92-bd24-d6bcaa502492 | |||||||||
| Reference Interval: |
Refer to report or laboratory |
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Collection Requirements |
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| Container: | Urine Container (URINE), | |||||||||
| Sample Type: | See container | |||||||||
| Minimum Collection Volume: | ||||||||||
| Collection Instructions: | For occupational exposure collect a spot urine after exposure or at the end of shift. See hyperlink for paperwork which must be completed and accompany sample. Non-medicare rebateable item. All patients except Public, VA and Pensioners must pay $375 upfront. |
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Processing Requirements |
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| Alternate Containers: |
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| Processing Instructions: | ||||||||||
| Minimum Assay Volume: | 20mL | |||||||||
| Stability: | ||||||||||
| Transport Instructions (to testing laboratory): | Send sample chilled. Requests should be reviewed by Duty Biochemist prior to transport. |
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Testing Locations |
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| Performed at: |
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Last Updated : 13-05-2025 12:18 |
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