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Heparin Induced Thrombocytopaenia Screen
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General
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Clinical Use:
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HIT is an immune mediated complication that may develop in patients exposed to heparin. The mechanism involves a heparin-dependent IgG - platelet factor 4 immune complex binding to the platelet FcRII consequently inducing platelet activation and destruction. Approximately 5% of patients treated with heparin develop HIT, which may be complicated by arterial and venous thrombosis due to intravascular platelet activation and endothelial damage. Thrombosis occurs in 20% of patients with HIT and may result in serious morbidity and mortality in about 50% of these patients. |
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Availability:
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Samples are tested routinely during the testing laboratory's hours of operation. |
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Aliases/Synonyms:
| Anti-PF4 Antibody, HITS, Platelet Factor 4, |
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Code:
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HIT |
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Handling Instructions (to laboratory):
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Send whole samples ambient. (Citrates & Serum)
Send separated samples (Citrates & Serum) frozen on dry ice if samples will not reach laboratory within 4 hours of collection. |
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Hyperlink:
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Reference Interval:
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Refer to report or laboratory
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Collection Requirements
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Container:
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Sodium Citrate-3.2% x 2 (BLUE), and, Serum Sep. Tube-SST (GOLD), and, Ampoule (AMPOULE), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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2.7mL |
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Collection Instructions:
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Record specific type of heparin on request form.
If samples will not reach laboratory within 4 hours of collection, they must be centrifuged, separated and frozen. (Citrates & Serum) |
Processing Requirements
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Alternate Containers:
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Processing Instructions:
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Process sample immediately on arrival in laboratory.
If all containers are not collected, contact the testing laboratory for advice. |
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Minimum Assay Volume:
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1mL |
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Stability:
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4 hours ambient |
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Transport Instructions (to testing laboratory):
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Send separated samples frozen on dry ice. (Citrates & Serum) |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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| Coagulation |
Haematology |
Fiona Stanley Hospital |
6152 8135 |
| Coagulation |
Haematology |
QEII Medical Centre |
6383 4006 |
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Last Updated : 08-11-2022 16:38 |