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General
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Clinical Use:
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An elevated mast cell tryptase is indicative of systemic mast cell degranulation. An increased level of serum tryptase, collected during an acute clinical event, is suggestive of anaphylaxis.
The predictive value is improved by comparing an acute with a baseline sample (=24hours post event). Anaphylaxis is not excluded if tryptase levels are within the normal range.
A persistently elevated baseline mast cell tryptase may occur in hereditary alpha tryptasaemia, systemic mastocytosis, other myeloid neoplasms and end stage renal failure. |
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Availability:
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Aliases/Synonyms:
| MCT, Tryptase, |
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Code:
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MCT |
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Handling Instructions (to laboratory):
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Send sample chilled. |
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Hyperlink:
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Unit of Measure:
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Refer to reference interval |
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Reference Interval:
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Refer to report or laboratory
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Collection Requirements
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Container:
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Serum Sep. Tube-SST (GOLD), |
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Sample Type:
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See Collection Instructions |
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Minimum Collection Volume:
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1ml |
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Collection Instructions:
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Lithium Heparin and EDTA plasma samples will be accepted in the absence of a serum sample for timed collections in emergency settings (Emergency departments and Ambulance collections).
Sample collections are recommended close to 1 - 2 hours after the event (no later than 4 hours), and a baseline level at least 24 hours after the event. |
Processing Requirements
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Alternate Containers:
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EDTA (LAVENDER) |
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Lithium Heparin-PST (GREEN) |
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Processing Instructions:
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When plasma samples are the only available sample, please change the sample type to Plasma under Specimen Attributes in SoftLab. |
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Minimum Assay Volume:
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200uL |
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Stability:
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5 days chilled; Indefinite when frozen |
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Transport Instructions (to testing laboratory):
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Send sample chilled. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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Immunology |
QEII Medical Centre |
6383 4306 |
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Last Updated : 10-04-2026 10:07 |