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General |
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| Clinical Use: | Lupus anticoagulants (LA) are autoantibodies directed against negatively charged phospholipids or complexes of phospholipids with either beta-2 glycoprotein 1 or clotting factors such as prothrombin. They occur in various clinical conditions especially autoimmune diseases and are associated in vivo with a tendency to thrombosis. LA are generally detected in phospholipid dependent clotting tests, (ie prolonged aPTT) but are not corrected by mixing studies with normal plasma. Prolonged clotting times due to a LA need to be distinguished from idiopathic antibodies against FVIII which are associated with bleeding. If patient is anticoagulated with a Direct Oral Anticoagulant (DOAC), a DOAC Stop test panel may be requested in addition to the Lupus anticoagulant to remove interference. (See DSLUP for additional information). |
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| Availability: | As required. Please contact testing laboratory for urgent requests. |
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| Aliases/Synonyms: | Antiphospholipid Screen, Dilute Russell Viper Venom Time, LA, LAC, | |||||||||||||
| Code: | LUP | |||||||||||||
| Handling Instructions (to laboratory): | Send whole sample ambient. Send separated sample frozen on dry ice. |
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| Hyperlink: | https://fasttrack.ict.pathwest.com.au/Portal/BRCF17.doc | |||||||||||||
| Reference Interval: |
Refer to report or laboratory |
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Collection Requirements |
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| Container: | Sodium Citrate-3.2% (BLUE), | |||||||||||||
| Sample Type: | See container | |||||||||||||
| Minimum Collection Volume: | 2.7mL | |||||||||||||
| Collection Instructions: | If sample will not reach laboratory within 4 hours of collection, it must be double centrifuged, separated and frozen. Refer to hyperlink for instructions. |
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Processing Requirements |
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| Alternate Containers: |
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| Processing Instructions: | ||||||||||||||
| Minimum Assay Volume: | 2.7mL, 1.8mL, 1.0mL MUST be filled to the correct level | |||||||||||||
| Stability: | 4 hours ambient | |||||||||||||
| Transport Instructions (to testing laboratory): | Send separated sample frozen on dry ice. | |||||||||||||
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Testing Locations |
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| Performed at: |
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Last Updated : 15-01-2025 14:26 |
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