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General
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Clinical Use:
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Pancreatic polypeptide (PPP) is secreted by the pancreas in response to all ingested nutrients and insulin-induced hypoglycaemia; it is mediated by vagal nerve stimulation.
Markedly elevated levels are often associated with benign or malignant functioning endocrine tumours of the pancreas (e.g., insulinoma, glucagonoma, gastrinoma). As well as Islet cell tumour metastases, duodenal ulcers, renal failure and some adenocarcinomas of the pancreas, stomach, colon and rectum. Elevated levels may also be characteristic of lean non-insulin dependent diabetes (NIDDM).
Low basal PPP levels may be a result of extensive pancreatic destruction (eg, chronic pancreatitis, pancreatic cancer) with exocrine insufficiency (an impaired response to hypoglycaemia by insulin or a meal). |
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Availability:
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Samples are batched and tested once a fortnight. |
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Aliases/Synonyms:
| PPP, |
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Code:
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PPP |
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Handling Instructions (to laboratory):
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Send separated sample frozen on dry ice. |
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Hyperlink:
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Reference Interval:
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< 50 years old < 55 pmol/L (fasting)
> 50 years old < 100 pmol/L
(fasting)
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Collection Requirements
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Container:
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Serum Sep. Tube-SST (GOLD), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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1mL |
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Collection Instructions:
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Patient must be fasting.
Sample must be centrifuged, separated and frozen immediately following collection. |
Processing Requirements
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Alternate Containers:
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Serum, no gel (RED) |
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Processing Instructions:
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Centrifuge, separate and freeze sample. |
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Minimum Assay Volume:
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0.5mL |
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Stability:
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Transport Instructions (to testing laboratory):
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Send separated sample frozen on dry ice.
Requests should be reviewed by Duty Biochemist prior to transport. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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Laboratory |
SSWPS-Royal Prince Alfred Hospital |
(02) 9515 8279 |
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Last Updated : 19-12-2025 11:42 |