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General
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Clinical Use:
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Vigabatrin (Sabril) is an anticonvulsant, GABA (Gamma-Aminobutyric Acid) Transaminase inhibitor, used for adjunctive therapy in epilepsy not controlled by other epileptic drugs.
Vigabatrin can cause progressive and permanent visual field defects in a high percentage
of patients and should not be used concomitantly with retinotoxic drugs. Other adverse events are mainly CNS-related, such as sedation, somnolence, fatigue and impaired concentration. |
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Availability:
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Aliases/Synonyms:
| Sabril, |
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Code:
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VIG |
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Handling Instructions (to laboratory):
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Send sample chilled. |
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Hyperlink:
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Reference Interval:
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No therapeutic range.
Vigabatrin plasma concentrations are related to dosage, but there is no strong correlation between plasma concentration and clinical effects. Out of 47 vigabatrin requests - 64% of these samples had plasma levels between 0 and 100 umol/L, 30% were between 100 and 200 umol/L, and 6% were between 200 and 700 umol/L. Trough levels were found within the range 19-43 umol/L (with a mean of 34 umol/L)
Conversion: umol/L x 0.12916 = ug/mL
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Collection Requirements
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Container:
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Serum, no gel (RED), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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Collection Instructions:
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Collect sample prior to dose as trough level.
Record date, time and dosage of last dose on request form. |
Processing Requirements
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Alternate Containers:
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Lithium Heparin, No Gel (DKGNLITH) |
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Processing Instructions:
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Centrifuge, separate and freeze sample. |
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Minimum Assay Volume:
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1mL |
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Stability:
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Transport Instructions (to testing laboratory):
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Send separated sample frozen on dry ice. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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Laboratory |
SSWPS-Royal Prince Alfred Hospital |
(02) 9515 8279 |
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Last Updated : 14-10-2020 13:16 |