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Tissue Transglutaminase Antibody
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General
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Clinical Use:
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IgA anti-transglutaminase antibodies (IgA-TTG) are directed against the major coeliac disease autoantigen and is the first line test for coeliac disease.
In people on a gluten-containing diet, the presence of IgA anti-TTG antibodies is highly sensitive and specific for coeliac disease (>95%).
IgA-TTG antibody level can assist in monitoring response to gluten-free diet in patients with coeliac disease.
Note: Total serum IgA is performed and result reported together with IgA-TTG. This is because i) patients with coeliac disease have a higher incidence of IgA deficiency and ii) sensitivity of IgA-TTG testing is reduced in patients with low serum IgA levels. Patients with total serum IgA levels < 0.2g/L will be tested for IgG antibodies to deamidated gliadin.
Due to the superior positive predictive value of IgA-tissue transglutaminase and IgG-deamidated gliadin antibodies for coeliac assessment, PathWest does not offer and will not refer testing for endomysial antibodies. |
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Availability:
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FSH: Samples are batched and tested once a week.
QEII: Samples are batched and tested twice a week. |
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Aliases/Synonyms:
| Anti-Endomysial Autoantibody, Anti-Gliadin Autoantibody, Anti-Gluten Autoantibody, Anti-TTG, Coeliac Disease Antibody Screen, Endomysial Autoantibody, Gliadin Autoantibody, Glutaminase Antibody, Gluten Autoantibody, IgA Anti-Tissue Transglutaminase Antibody, Transglutaminase Antibody, TTA, TTG IgA, |
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Code:
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COELS |
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Handling Instructions (to laboratory):
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Send sample chilled. |
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Hyperlink:
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Reference Interval:
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Refer to report or laboratory
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Collection Requirements
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Container:
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Serum Sep. Tube-SST x 2 (GOLD), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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1ml |
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Collection Instructions:
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Processing Requirements
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Alternate Containers:
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Processing Instructions:
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Minimum Assay Volume:
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200uL |
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Stability:
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7 days chilled. |
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Transport Instructions (to testing laboratory):
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Send sample chilled. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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Immunology |
Fiona Stanley Hospital |
6152 8006 |
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Immunology |
QEII Medical Centre |
6383 4306 |
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Last Updated : 07-07-2025 14:31 |