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General
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Clinical Use:
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To determine the concentration of tobramycin in the blood in order to maintain a therapeutic level or to detect a toxic level.
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Availability:
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Samples are tested routinely during the testing laboratory's hours of operation. |
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Code:
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TOB |
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Handling Instructions (to laboratory):
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Send sample chilled. |
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Hyperlink:
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Reference Interval:
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Monitoring of the aminoglycoside plasma concentrations should begin from the first dose if used for directed therapy, or if empiric therapy is planned to extend beyond 48 hours.
Monitoring is essential to maximise efficacy and to prevent toxicity.
For once daily dosing a computerised method approach is recommended. This requires two plasma concentrations (peak and post dose levels)
entered into a computer program to calculate drug exposure. Discuss with a Clinical Pharmacist regarding locally available calculators.
Trough levels should remain below the detectability of the assay.
For multiple-daily, synergistic dosing regimens (8 to 12 hourly) of gentamicin (eg for endocarditis), measure a trough (pre-dose) concentration, aiming for 0.5 to 1mg/L.
For prolonged courses of aminoglycoside therapy (>7 days) or where high cumulative aminoglycoside exposure has occurred, regular clinical and audiologic monitoring
is strongly recommended due to the risk of ototoxicity.
Contact an Infectious Disease Physician, Clinical Microbiologist or Clinical Pharmacist for further advice on dosing and therapeutic monitoring.
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Collection Requirements
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Container:
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Lithium Heparin-PST (GREEN), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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300uL |
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Collection Instructions:
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If sample will not reach laboratory within 24 hours of collection, it must be centrifuged and separated from gel. Alternatively a non-gel tube should be used. |
Processing Requirements
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Alternate Containers:
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Lithium Heparin, No Gel (DKGNLITH) |
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Serum, no gel (RED) |
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Processing Instructions:
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Minimum Assay Volume:
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150uL |
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Stability:
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24 hours chilled (unseparated); 7 days chilled (separated) |
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Transport Instructions (to testing laboratory):
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Send sample chilled. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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| Core |
Biochemistry |
Fiona Stanley Hospital |
6152 8140 |
| Core |
Biochemistry |
QEII Medical Centre |
6383 4093 |
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Last Updated : 14-10-2020 14:47 |