|
|
General
|
| |
Clinical Use:
|
Chromogranin A is an acidic protein that is co-released with catecholamines from storage granules in the adrenal medulla. It is secreted by a great variety of peptide-producing endocrine neoplasms: pheochromocytoma, parathyroid adenoma, medullary thyroid carcinoma, carcinoids, oat-cell lung cancer, pancreatic islet-cell tumours, and aortic-body tumour. Non-tumour associated increases may occur with proton-pump inhibitor use, gastritis, impaired renal and liver function,inflammatory bowel disease, glucocorticoid therapy and high titres of rheumatoid factor. |
| |
Availability:
|
Samples are batched and tested once a week. |
| |
Aliases/Synonyms:
| CgA, Cgn, |
| |
Code:
|
CGA |
| |
Handling Instructions (to laboratory):
|
Send separated sample frozen on dry ice. |
| |
Hyperlink:
|
|
| |
Reference Interval:
|
Chromogranin A: <102 ug/L
In most patients treated with PPI a two to four-fold increase in CgA is found.
The increase in CgA seems to be related to the dosage and duration of PPI treatment.
A more than ten-fold increase in CgA levels has occassionally been reported.
One to two weeks after discontinuation of PPI the CgA levels return to normal.
|
Collection Requirements
|
| |
Container:
|
Serum Sep. Tube-SST (GOLD), |
| |
Sample Type:
|
See container |
| |
Minimum Collection Volume:
|
1mL |
| |
Collection Instructions:
|
Non Medicare Rebateable item. All patients except Public, VA and Pensioners must pay $50.75 upfront. |
Processing Requirements
|
| |
Alternate Containers:
|
|
| |
Processing Instructions:
|
Centrifuge, separate and freeze sample. |
| |
Minimum Assay Volume:
|
250uL |
| |
Stability:
|
48 hours chilled; 6 months frozen |
| |
Transport Instructions (to testing laboratory):
|
Send separated sample frozen on dry ice. |
Testing Locations
|
| |
Performed at:
|
|
Section
|
Department
|
Site
|
Contact Phone
|
| Special Chemistry |
Biochemistry |
Fiona Stanley Hospital |
6152 2830 |
|
Last Updated : 11-08-2021 14:29 |