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General
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Clinical Use:
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Concentrations of Homocysteine(HCY)are increased in 15-40% of patients with coronary, cerebral or peripheral arterial disease. This association is independent from most other risk factors for arteriosclerosis, for example the lipid factors. HCY is thought to be a toxic factor directly involved in vascular cell wall damage. A clinically important observation is that high HCY may be corrected by folic acid, occasionally supplemented with vitamin B12 or pyridoxine. Elevated HCY levels are a marker of vitamin deficiency, especially folate and will often respond to folate supplementation. HCY may be elevated in patients with chronic kidney disease due to impaired removal from the blood by the kidney. There is a graded increase in the risk of stroke as HCY levels rise. Markedly high concentrations of HCY occur in patients with homocystinuria - a rare, inherited disorder of metabolism. |
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Availability:
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Samples are tested routinely during the testing laboratory's hours of operation. |
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Code:
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HCY |
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Handling Instructions (to laboratory):
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Send sample chilled. |
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Hyperlink:
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Reference Interval:
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0m-6 months: 4-13
7m- 10 yrs: 3.0-8.0
11y-15 yrs: 4.0-10.0
16y-18 yrs: 4.0-11.0
>18yrs Male: 8.0-14.0
>18yrs Female:6.0-12.0
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Collection Requirements
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Container:
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Serum Sep. Tube-SST (GOLD), |
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Sample Type:
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See container |
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Minimum Collection Volume:
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1mL |
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Collection Instructions:
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If sample will not reach laboratory within 1 hour of collection, it must be centrifuged to separate plasma from red cells. |
Processing Requirements
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Alternate Containers:
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Lithium Heparin-PST (GREEN) |
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Processing Instructions:
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Minimum Assay Volume:
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250uL |
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Stability:
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1 hour ambient (unseparated); 5 days chilled (separated); 2 years frozen |
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Transport Instructions (to testing laboratory):
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Send sample chilled. |
Testing Locations
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Performed at:
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Section
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Department
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Site
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Contact Phone
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| Core |
Biochemistry |
Fiona Stanley Hospital |
6152 8140 |
| Core |
Biochemistry |
QEII Medical Centre |
6383 4093 |
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Last Updated : 21-10-2020 14:54 |